The property from which the Tivoli Nightclub in Buckley is run is going to auction with a guide price of between £250,000 and £300,000.
Chris Murphy, from agents Dodds Property World in Mold, said a date for the auction has not yet been set and said there is no specific request to keep the building on Brunswick Road as a nightclub.
He said: "It is the sale of the property, there is no requirement for the business to continue.
"New owners could go for a change of use, if that's what they decide to do with it."
However, the club is still currently open for business and has forthcoming events advertised.
The building was originally listed on another agent's website, where it is said to have the potential for redevelopment.
When listed with James A Baker property consultants, it describes the Tivoli as a 'well known as a premier North Wales nightspot', adding: "Presently trading three nights a week with a fourth night monthly, the venue attracts crowds from both Chester and Wrexham.
"The property, with its close proximity to major retailers and other businesses, may offer scope for redevelopment potential for residential, retail or other commercial use, subject to permissions."
People from the town and across the region hold fond memories of the club, known to many as the Tiv, which has been running for a number of years, and between the 1930s and 1950s was a cinema and theatre.
The stage at the venue has been graced by many bands down the years for live gigs, including early performances by Radiohead and Oasis.
Carol Shone from the Buckley Society, which promotes the heritage of the town, said: "The Tiv means an awful lot to people in Buckley.
"It's still very popular."
Buckley Cllr Ron Hampson said: "I think it would be a loss to the area if it went – it's very popular and people come from other areas to go there.
"It's part of the establishment of the town.
"Young people need somewhere to go – I think they would be disappointed if it went for a change of use.
"It's had some bad phases but it's been a well-run nightclub in the last few years."
The Tivoli had recently undergone a facelift, and the owners, Company Time Ltd, were working alongside the town's neighbourhood policing team to ensure clubbers enjoyed themselves without disturbing nearby residents.
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